1293 - 1538 and the start of the plagues
In 1293 the manor in Lockerley was granted to John Butler (Le Boteler) by King Edward I (b 17 June 1239 and ruled from 1272 till his death in 7 July 1307) Information on the other two manors referenced in the Domesday Book may possibly found by researching the history of Holbury and East Tytherley.
In this period the name was spelt Locherslei but it was also known as Lockerley Boteler and Lockerley Butler. As it happens, Butlers Close is named after Stephen Butler a parish councillor ca 1960 and he is not, knowingly, related to the historical reference. It is possible that the location known as Butlers Barn, in Mount Lane, may reflect the earlier historical ownership.
John Butler died in 1310 and he left the manor to his son (also John) who, in turn, designated it to his mother as a dower until her death. Of local note one John Payne was known to hold the area known as Painshill because, between 1333 and 1345 (his death) he had acquired a licence from the Bishop of Winchester to hear divine oratory within his home due poor health. This area is very likely to be that currently known as Painshill Farm and the lane leading to it south east from Lockerley is known as Pains Hill. 

In 1346 Holbury - which you may recall was also included within East Tytherley at the time - was used by Queen Philippa. She was 16 when she married the 15 year old King Edward III in York Minster in January 1328 just in his first year as reigning king following the deposition of his father Edward II in January 1327. She seems to have had the use of the place since 1335 and she moved there with her court in order to avoid the first wave of the Black Death. It seems that two of her court were, or became, infected and that much of East Tytherley succumbed.

Historians estimate that the typical cull of the black death - bubonic plage - was around 30% and that infection was very rapid.  The disease had three forms. The mildest was around 80% fatal within seven days whilst the fastest, the septicaemic form which produced the dark patches under the skin known as purpura, was nearly 100% fatal. Historians suggest that the likely source of the disease was the far east and that the likely entry point may have been the mediterranean Genoese and Venetian traders who worked into Southampton and Weymouth. Phillipa lost two of her 14 children to the disease in 1348.  It's possible that the area of East Tytherley and Lockerley were strongly affected also and that might explain the absence of a village centre for East Tytherley though there is evidence that there was habitation - now vanished - in Buckholt.

One side effect of the royal court sequestering itself in East Tytherley was a dislike in the area for royalty.  This dislike was not shared by the neighbouring West Tytherley and so each village supported a different side during the English civil war.  

In 1348 John (son of John Butler) requested a licence from the king to have the Lockerley manor settled on himself and his wife Margery. He died in 1349 but the licence seems to have been granted to his son and heir some time later - in 1375. One Lewis John - a nice coincidental twist given the model farm operated by the John Lewis partnership in Leckford a few kilometres north out side Stockbridge - held the manor in custody for the heir of a person by the name of Francis Court. By 1476 the land at Holbury and Lockerley was included within the manor of East Tytherley. The manor at East Tytherley was probably that identified as held by Gilbert de Breteuil in 1086 as an overlord and previously held by Chening in alod from Edward the Confessor.

The Middle Ages
History passes and somehow the manor passes back to the crown which, in 1493, granted it to George Bainbridge. He was also granted East Tytherley manor in 1496 along with Butler's estate in Lockerley.  In charting the passage and use of land it will be useful to access the  tither maps for farms in this area [EG IMAGE TITHE MAP GAMBLEDOWN].  These maps are also a primary resource in establishing the rights of passage along footpaths. Where a passage between two places follows the borders - or it may be across a field - leased or owned by more than one person then there exists a de facto right of passage.  This right can not, in principle be taken away - it is for all time and does not evaporate if the route is no longer used.  A large number of such paths were removed during the ages of the Acts of Inclosure [CHECK DATES AND DETAILS].  The impact of these acts can be seen in those counties where the act was more energetically carried out.  Hampshire - in general - seems to have not been as extensively affected and there exists in Hampshire a healthy collection of such rights of way [LINK TO TAB ON FOOTPATHS].  However since ca 1923 [ROAD TRAFFIC ACTS &C CHECK] county councils have had to identify rights of way and to publish the details on Definitive Map of Rights of Way.  Broadly they are responsible for the maintenance of the access points - stiles and gates - to the paths and this is a responsibility that rests also with the landowner.